Which csf may be prescribed to treat neutropenia?

Last Update: May 27, 2022

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Asked by: Dr. Luther Schamberger V
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A G-CSF is a drug that doctors prescribe for treating neutropenia. Neutropenia is a condition that causes a person's white blood cell level to drop below normal. White blood cells can drop in people with some types of cancer and those taking certain medications, such as chemotherapy.

What is G-CSF for neutropenia?

A drug used under the brand names Neupogen, Zarxio, and Nivestym to treat neutropenia (a lower-than-normal number of white blood cells), prevent infection, and prepare the blood for the collection of certain types of blood cells, and under the brand name Granix to treat neutropenia.

What CSF can be used to increase neutrophils?

G-CSF is used in two ways. It is given: during treatment with chemotherapy, to stimulate the bone marrow to make white blood cells. These cells are called neutrophils.

When do you use G-CSF?

Filgrastim is used to stimulate the production of granulocytes (a type of white blood cell) in patients undergoing therapy that will cause low white blood cell counts. This medication is used to prevent infection and neutropenic (low white blood cells) fevers caused by chemotherapy. Filgrastim is a support medication.

What is G-CSF pegfilgrastim used for?

It is used to reduce the incidence of fever and infection in patients with certain types of cancer who are receiving chemotherapy that affects the bone marrow, to stimulate blood cell production for removal of WBCs from the body prior to a bone marrow transplantation, to reduce the incidence of fever and infection in ...

What is febrile neutropaenia (neutropenia)? - neutrophil function, pathophysiology, treatment

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When do you stop G-CSF?

Autologous transplants - Stop the G-CSF after 2 consecutive days of neutrophils >1.0 x 109/l. Note: Longer-acting Pegylated G-CSF is not approved for use in this setting.

How quickly does G-CSF work?

This usually takes 5 to 7 days, although it can be longer. Long-acting G-CSF is given as a single injection the day after chemotherapy has completed. If you are having G-CSF before a stem cell transplant, you usually have your first injection 4 to 6 days before your stem cells are going to be collected.

Can G-CSF cause leukemia?

G-CSF use has been associated with later development of myelodysplastic syndromes/acute myelogenous leukemia (MDS/AML) in several clinical circumstances.

Does G-CSF increased platelets?

G-CSF administration induces an inflammatory process with endothelial cell activation. This is probably the reason why platelet volume increases after G-CSF use.

What drug stimulates the production of white blood cells?

Filgrastim is used to stimulate the production of granulocytes (a type of white blood cell) in patients undergoing therapy that will cause low white blood cell counts. This medication is used to prevent infection and neutropenic (low white blood cells) fevers caused by chemotherapy. Filgrastim is a support medication.

What injection is given to increase white blood cells?

1 Neupogen works by stimulating the bone marrow to increase the production of white blood cells. It is a clear liquid that is usually given as a shot (injection).

What are the cause of neutropenia?

Chemotherapy is one of the most common causes of neutropenia. Cancer and other blood and/or bone marrow disorders. Deficiencies in vitamins or minerals, such as vitamin B12, folate, or copper. Autoimmune diseases, including Crohn's disease, lupus, and rheumatoid arthritis.

Is myelosuppression the same as bone marrow suppression?

Myelosuppression, also known as bone marrow suppression, is a decrease in bone marrow activity that results in reduced production of blood cells. Some blood cell disorders include: fewer red blood cells (anemia)

Where is G-CSF found?

The G-CSF-receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates proliferation and differentiation into mature granulocytes. G-CSF stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils.

How do you increase your neutrophil count?

Eating foods rich in B-12 may help improve low neutrophil blood levels. Examples of foods rich in vitamin B-12 include: eggs. milk and other dairy products.
...
How to raise and lower levels
  1. colony-stimulating factors.
  2. corticosteroids.
  3. anti-thymocyte globulin.
  4. bone marrow or stem cell transplantation.

What is the brand name for filgrastim?

Neupogen, Granix and Zarxio are trade names for filgrastim. Granulocyte - colony stimulating factor (G-CSF) is another name for filgrastim.

What produces G-CSF?

Human G-CSF is produced mainly by monocytes and macrophages (2), but is also produced by fibroblasts (3), endothelial cells (4), and bone marrow stromal cells (5).

Can filgrastim cause leukemia?

This medicine may cause blood or bone marrow problems (eg, myelodysplastic syndrome, acute myeloid leukemia) in patients with breast or lung cancer.

How do you give a CSF injection?

After the needle is inserted, let go of your skin. Use your thumb (whichever thumb is more comfortable) to slowly push the plunger all the way down. Push it until all the medication is injected. When the syringe is empty, pull it straight out of your skin.

How do you stimulate bone marrow growth?

Bone marrow stimulants

Certain drugs — including colony-stimulating factors, such as sargramostim (Leukine), filgrastim (Neupogen) and pegfilgrastim (Neulasta), epoetin alfa (Epogen/Procrit), and eltrombopag (Promacta) — help stimulate the bone marrow to produce new blood cells.

Why is G-CSF given 24 hours after chemo?

Post-chemotherapy prophylactic granulocyte colony-stimulating factor (G-CSF) is customarily started 24 hours after chemotherapy in most of the current pediatric and adult solid tumors protocols to ameliorate the myelotoxicity of cytotoxic agents and reduce neutropenia-related complications.

Where do you inject G-CSF?

You usually have injections under the skin (subcutaneous injection) into the stomach, thigh or top of your arm. You might have stinging or a dull ache for a short time after this type of injection but they don't usually hurt much. The skin in the area may go red and itchy for a while.

What are the side effects of filgrastim?

Filgrastim injection products may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • redness, swelling, bruising, itching or a lump in the place where the medication was injected.
  • bone, joint, back, arm, leg, mouth, throat, or muscle pain.
  • headache.
  • rash.
  • constipation.
  • diarrhea.
  • nausea.